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Polynucleotides (PNs)
Polynucleotides for Skin Regeneration
From £280 - £400 per session
At Dr Hans Clinics, we offer Polynucleotides – a cutting-edge skin rejuvenation treatment that promotes cell regeneration, hydration, and collagen production. This non-invasive procedure restores your skin’s youthful glow, visibly reducing signs of ageing, dullness, and dehydration. Ideal for achieving a hydrated, radiant complexion.
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What They Are
Polynucleotides are highly purified chains of DNA fragments derived from salmon DNA, used in regenerative medicine for their:
● Anti-inflammatory properties.
● Fibroblast stimulation.
● Tissue repair acceleration.
Brands we use:
● Plinest® (Mastelli, Italy) – original patented PN product.
● Croma Phil® – newer PN injectable with CE-mark.
● Anti-inflammatory properties.
● Fibroblast stimulation.
● Tissue repair acceleration.
Brands we use:
● Plinest® (Mastelli, Italy) – original patented PN product.
● Croma Phil® – newer PN injectable with CE-mark.
Mechanism of Action
● Binds to adenosine receptors → reduces inflammation.
● Fibroblast stimulation → increases type I collagen and hyaluronic acid synthesis.
● Scavenges free radicals → antioxidant action.
● Improves angiogenesis → better skin perfusion and hydration.
● Fibroblast stimulation → increases type I collagen and hyaluronic acid synthesis.
● Scavenges free radicals → antioxidant action.
● Improves angiogenesis → better skin perfusion and hydration.
Where We Use PNs
● Eyes → tear trough hollows, dark circles, fine lines.
● Face → overall rejuvenation, fine lines.
● Neck → laxity and skin texture.
● Scars → acne or trauma scars.
● Body → stretch marks, post-surgical scars.
● As microneedling boosters → combined with dermastamp for synergistic collagen induction.
● As topical enhancers → post-energy-based treatments for faster recovery (+£150).
● Face → overall rejuvenation, fine lines.
● Neck → laxity and skin texture.
● Scars → acne or trauma scars.
● Body → stretch marks, post-surgical scars.
● As microneedling boosters → combined with dermastamp for synergistic collagen induction.
● As topical enhancers → post-energy-based treatments for faster recovery (+£150).
Where We Don’t Use PNs
● We avoid high-volume or aggressive protocols (overhyped online) as results plateau.
● We don’t position them as a substitute for fillers or surgery – they are regenerative, not volumising.
● We don’t position them as a substitute for fillers or surgery – they are regenerative, not volumising.
Evidence
● Cervelli et al, J Cell Physiol 2015 – PNs accelerate fibroblast proliferation and collagen deposition.
● Cervelli et al, Aesthetic Plast Surg 2010 – significant improvement in periorbital wrinkles with PNs.
● Mastelli studies – document safety and efficacy in scar treatment and skin rejuvenation.
● Cervelli et al, Aesthetic Plast Surg 2010 – significant improvement in periorbital wrinkles with PNs.
● Mastelli studies – document safety and efficacy in scar treatment and skin rejuvenation.
What Are Polynucleotides?
Polynucleotides (PNs) are purified DNA fragments (from salmon DNA) that act as powerful biostimulators. They reduce inflammation, boost collagen production, and repair damaged tissue.
Brands we use:
● Plinest® (Mastelli) – the original patented PN.
● Croma Phil® – high-purity CE-marked PN.
Brands we use:
● Plinest® (Mastelli) – the original patented PN.
● Croma Phil® – high-purity CE-marked PN.
How Polynucleotides Work (Mechanism of Action)
● Anti-inflammatory reset → bind adenosine receptors, calming inflamed skin.
● Fibroblast stimulation → increase type I collagen and hyaluronic acid production.
● Antioxidant scavenging → neutralise free radicals.
● Angiogenesis → boost blood supply for healthier, plumper skin.
● Fibroblast stimulation → increase type I collagen and hyaluronic acid production.
● Antioxidant scavenging → neutralise free radicals.
● Angiogenesis → boost blood supply for healthier, plumper skin.
Where We Use Polynucleotides
● Eyes → tear trough hollows, dark circles, fine lines.
● Face → rejuvenation, pigmentation, fine lines.
● Neck → laxity, sagging, texture.
● Scars → acne, trauma, post-surgical.
● Body → stretch marks, skin laxity.
● Microneedling boosters → dermastamp-assisted delivery.
● Post-energy-based devices → speeds recovery (+£150).
● Face → rejuvenation, pigmentation, fine lines.
● Neck → laxity, sagging, texture.
● Scars → acne, trauma, post-surgical.
● Body → stretch marks, skin laxity.
● Microneedling boosters → dermastamp-assisted delivery.
● Post-energy-based devices → speeds recovery (+£150).
Where We Don’t Use PNs
● Not marketed as a “filler” or substitute for surgery.
● We avoid over-aggressive, over-promised protocols.
● We avoid over-aggressive, over-promised protocols.
Evidence
● Cervelli et al, J Cell Physiol 2015 → fibroblast proliferation, collagen stimulation.
● Cervelli et al, Aesthetic Plast Surg 2010 → PN effective for eye wrinkles.
● Mastelli clinical data → scar healing and rejuvenation outcomes.
● Cervelli et al, Aesthetic Plast Surg 2010 → PN effective for eye wrinkles.
● Mastelli clinical data → scar healing and rejuvenation outcomes.
FAQ'S
Are polynucleotides fillers?
No, they don’t add volume. They regenerate skin quality and structure.
How many treatments are needed?
Usually 3-4 spaced monthly, then maintenance.
Are they safe?
Yes. PNs are highly purified, biocompatible, and CE-certified.
Pricing
-
Eyes £280
(single session)
-
Eyes £790
(Package of 3 session)
-
Face £350
(single session)
-
Face £1000
(Package of 3 session)
-
Scars £280
(single session)
-
Scars £790
(Package of 3 session)
-
Neck £300
(single session)
-
Neck £850
(Package of 3 session)
-
Body £400
(single session)
-
Body £1150
(Package of 3 session)
Microneedling add-ons: +£150 (single) | +£100 (package).