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Combination: Hyperdilute Radiesse + PRF Biofiller (Plasma Gel / EZ Gel)
Restore Radiance, Naturally
From £650 per session
At Dr Hans Clinics, the Hyperdilute Radiesse + PRF Biofiller (Plasma Gel / EZ Gel) is your go-to natural Biostimulation. Discover your most radiant skin today.
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Why Combine?
Hyperdilute Radiesse and PRF Biofiller target different biological pathways:
● Hyperdilute Radiesse: stimulates fibroblasts to rebuild collagen and elastin → long-term improvement in skin quality.
● PRF Biofiller (Plasma Gel/EZ Gel): provides a short-term scaffold and hydration, plus growth factors when combined with liquid PRF.
Together, they deliver both immediate plumpness (from the gel) and long-lasting regeneration (from Radiesse).
● Hyperdilute Radiesse: stimulates fibroblasts to rebuild collagen and elastin → long-term improvement in skin quality.
● PRF Biofiller (Plasma Gel/EZ Gel): provides a short-term scaffold and hydration, plus growth factors when combined with liquid PRF.
Together, they deliver both immediate plumpness (from the gel) and long-lasting regeneration (from Radiesse).
Mechanism of Action (simplified flow):
1. PRF Biofiller – plasma proteins + PRF create a temporary matrix → adds volume & hydration.
2. Radiesse CaHA microspheres – stimulate fibroblasts → collagen & elastin synthesis.
3. Combined effect – short-term visible improvement + long-term skin strengthening.
2. Radiesse CaHA microspheres – stimulate fibroblasts → collagen & elastin synthesis.
3. Combined effect – short-term visible improvement + long-term skin strengthening.
Evidence & Transparency
● Evidence for Radiesse biostimulation is well established.
● Evidence for plasma gel is more limited, with short duration (3–6 months).
● Combination is a clinical approach that may enhance overall outcomes, but it is not yet validated in large comparative trials.
● Patients must understand this is not a permanent filler — maintenance is required.
● Evidence for plasma gel is more limited, with short duration (3–6 months).
● Combination is a clinical approach that may enhance overall outcomes, but it is not yet validated in large comparative trials.
● Patients must understand this is not a permanent filler — maintenance is required.
Who is it for?
✅ Patients seeking both short-term rejuvenation and long-term collagen stimulation.
✅ Those preferring to limit synthetic fillers, but still open to advanced regenerative combinations.
❌ Not suitable for patients expecting permanent, one-off results.
✅ Those preferring to limit synthetic fillers, but still open to advanced regenerative combinations.
❌ Not suitable for patients expecting permanent, one-off results.