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Regenerate deeper.
Book your combination biostimulation session at Dr Hans Clinics, London.
Hyperdilute Radiesse + PRF Biofiller - biostimulator
Combination Therapy - Hyperdilute Radiesse + PRF Biofiller
This advanced regenerative protocol combines Calcium Hydroxylapatite (Radiesse) with Platelet-Rich Fibrin (PRF EZ Gel) to enhance collagen synthesis, tissue hydration, and dermal elasticity.
The synergy of mechanical stimulation (Radiesse) and biological signalling (PRF growth factors) delivers multi-layered rejuvenation in one session.
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MECHANISM OF ACTION
● Radiesse : Activates fibroblasts and provides structural collagen induction.
● PRF Biofiller: : Delivers autologous growth factors (PDGF, TGF-β, VEGF) that accelerate cell regeneration and improve vascularisation.
● Combined, they enhance both extracellular matrix integrity and cellular turnover.
Onset : Visible within 4 weeks Peak : 812 weeks Duration : 12–18 months
● PRF Biofiller: : Delivers autologous growth factors (PDGF, TGF-β, VEGF) that accelerate cell regeneration and improve vascularisation.
● Combined, they enhance both extracellular matrix integrity and cellular turnover.
Onset : Visible within 4 weeks Peak : 812 weeks Duration : 12–18 months
WHY PATIENTS CHOOSE DR HANS CLINICS
● Doctor-led regenerative protocols combining evidence-based technologies.
● Precise dilution and layering to stimulate collagen while maintaining softness.
● Ideal for face, neck, hands, or décolletage.
● Precise dilution and layering to stimulate collagen while maintaining softness.
● Ideal for face, neck, hands, or décolletage.
EVIDENCE & SAFETY
● Emerging clinical data shows enhanced fibroblast density and angiogenesis when CaHA is combined with platelet-derived matrices (Sclafani 2022; Goldberg 2021).
● Swelling and tenderness typically subside in 24 – 48 hours.
● Performed under sterile, CE-compliant conditions.
● Swelling and tenderness typically subside in 24 – 48 hours.
● Performed under sterile, CE-compliant conditions.
TREATMENT PLAN
● Procedure : 60 minutes including consultation.
● Course : 1 – 2 sessions, 8 weeks apart.
● Maintenance : Annually.
● Anaesthesia : Topical or local if required.
● Course : 1 – 2 sessions, 8 weeks apart.
● Maintenance : Annually.
● Anaesthesia : Topical or local if required.
COMPLIANCE STATEMENT
● Both components (Radiesse® – CE Class III; PRF EZ Gel – autologous) are administered only by medical professionals under aseptic conditions.
● Not a replacement for surgery. Results vary with age, baseline collagen, and individual healing.
● Not a replacement for surgery. Results vary with age, baseline collagen, and individual healing.
Pricing
Each treatment tailored to area, dilution, and tissue thickness.
FAQs
Why combine?
Structure + autologous signalling; chosen when tissues need both scaffold and quality support.
Safety?
We stage/sequence to reduce inflammation risk; not for active dermatitis/infection.