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Hyperdilute Radiesse + PRF Biofiller in London

Combination Therapy – Hyperdilute Radiesse + PRF Biofiller

- From £650 per session

Duration

45-60 minutes

Sessions

1

Pounds

Price

£650

Downtime

Mild swelling

Key Benefits

Stimulates natural collagen production
Improves skin firmness and elasticity
Enhances skin hydration and texture
Supports dermal regeneration
Improves the appearance of fine lines and crepey skin
Provides subtle, natural-looking skin rejuvenation
Combines CaHA collagen stimulation with autologous PRF growth factors
Supports improved tissue quality without significant over-volumisation
Progressive improvement in skin quality and elasticity
Suitable for personalised combination regenerative protocols

Target Areas

Face
Lower Face & Jawline
Neck
Décolletage
Hands
Areas of Skin Laxity
Fine Lines & Crepey Skin
Areas of Mild Volume Loss

What It Is

This advanced regenerative protocol combines Calcium Hydroxylapatite (Radiesse) with Platelet-Rich Fibrin (PRF EZ Gel) to enhance collagen synthesis, tissue hydration, and dermal elasticity.

The synergy of mechanical stimulation (Radiesse) and biological signalling (PRF growth factors) delivers multi-layered rejuvenation in one session.

Mechanism Of Action

Radiesse : Activates fibroblasts and provides structural collagen induction.
PRF Biofiller: : Delivers autologous growth factors (PDGF, TGF-β, VEGF) that accelerate cell regeneration and improve vascularisation.
Combined, they enhance both extracellular matrix integrity and cellular turnover.
Onset : Visible within 4 weeks
Peak : 812 weeks
Duration : 12–18 months

Why Patients Choose Dr Hans Clinics

Doctor-led regenerative protocols combining evidence-based technologies.
Precise dilution and layering to stimulate collagen while maintaining softness.
Ideal for face, neck, hands, or décolletage

Evidence & Safety

Emerging clinical data shows enhanced fibroblast density and angiogenesis when CaHA is combined with platelet-derived matrices (Sclafani 2022; Goldberg 2021).
Swelling and tenderness typically subside in 24 - 48 hours.
Performed under sterile, CE-compliant conditions.

Treatment Plan

Procedure : 60 minutes including consultation.
Course : 1 - 2 sessions, 8 weeks apart.
Maintenance : Annually.
Anaesthesia : Topical or local if required.

Compliance Statement

Both components (Radiesse® - CE Class III; PRF EZ Gel - autologous) are administered only by medical professionals under aseptic conditions.
Not a replacement for surgery. Results vary with age, baseline collagen, and individual healing.

Dr Hans Clinics : Protocol and workflow

Comprehensive Consultation & Skin Assessment

Medical History & Suitability Review

Skin Quality, Laxity & Volume Assessment

Clinical Photography & Treatment Mapping

Personalised Combination Treatment Planning

Blood Collection for PRF Preparation

PRF Processing & Biofiller Preparation

Hyperdilute Radiesse® Preparation

Treatment Area Cleansing & Preparation

Precision Radiesse® & PRF Biofiller Application

Collagen & Regenerative Biostimulation

Post-Treatment Assessment

Aftercare & Recovery Guidance

Follow-Up & Progress Review

Maintenance Treatment Planning

Clinical Before & After Results

Pricing

Each treatment tailored to area, dilution, and tissue thickness.

A Note on Transparency

PRF EZ Gel Biofiller is frequently marketed in ways that overstate what it does. Claims of long-lasting structural volume, permanent regeneration, or results comparable to dermal fillers aren’t supported by the current evidence. The published literature on plasma gel treatments is still relatively limited, and most studies are small and early in their design.

What we can say with reasonable confidence: PRF Biofiller improves subtle hollowing and early volume loss in suitable patients, delivers some regenerative stimulus through the PRF component, and does so without synthetic material. Results are real but modest, and maintenance is part of the treatment.

We think patients deserve to know that before they book. The consultation is where we work out whether this treatment makes sense for you, and if something else would work better, we’ll recommend that instead.

Our Treatment Specialists

Dr Hansel

Dr. Hansel Misquitta

Founder | Dr. Hans Clinics

MBBS | MSc Plastic & Reconstructive Surgery (UCL) | PGDip Bioethics (UNESCO Chair)

FAQ's

Why combine?

Structure + autologous signalling; chosen when tissues need both scaffold and quality support.

We stage/sequence to reduce inflammation risk; not for active dermatitis/infection.

Reviews

Semih
Before booking PRF EZ Gel for my under eyes, I had a lot of questions and concerns. Dr Hans took time to go through all of them properly and did not rush the consultation. She explained the treatment in a balanced way and set realistic expectations. The procedure itself was more comfortable than I imagined and the result looks very natural. My face looks more rested rather than noticeably treated, which was important to me.
Elene Gelashvili
I had a great experience with Dr. Hans. I wanted to do Ez gel under my eyes. She listened to my concerns and took her time to explain why it wouldn’t be suitable treatment for me. Instead we agreed to tighten my skin with Tixel - I had 3 sessions, very happy with the results.
Rachael Epstein
Absolutely the most knowledgeable and kindest doctor I’ve met. I’ve had injectables and PRF and soon tixel with her. She makes you feel so comfortable and confident. She will also say no and not just try to sell which is so important. She truly wants to improve the life of others which isn’t the case throughout the aesthetic industry (a lot of people try to exploit insecurities) and I used to work in it so I know! Thank you so much

Treatment Location

Regenerate deeper.

Book your combination biostimulation session at Dr Hans Clinics, London.

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